(telmisartan) blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively inhibiting the binding of angiotensin II to the AT1 receptor in many tissues. This vasodilating effect leads to a decrease in blood pressure and renal fluid retention.
(Peroxisome Proliferator-Activated Receptor-gamma), which is also targeted by glitazones. Activation of PPAR-γ is suggested to help regulate carbohydrate and lipid metabolism. Of all the commercially available ARBs, Pritor
is the only one demonstrated to have potential for this dual activity, which may translate into real benefits for the treatment of diabetes and metabolic syndrome.
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is not known to bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
